What worsening uneven temperatures actually mean
Uneven room temperatures that keep getting worse are a distribution problem. Your equipment is probably fine. The air just isn't reaching where it should.
The key word is 'worsening.' A house with one always-cold room usually has a fixed design flaw. When the gap grows month over month, something is failing in the ducts.
The usual suspects: a duct that fell off its connection, joints leaking more as old sealant cracks, a crushed flex insulation that slid off, or a damper that drifted out of balance.
The good news is that a lot of this is visible and fixable if you can safely reach the ducts. The bad news is that the worst leaks are often exactly where you can't easily get to them.
The most likely causes, ranked
Start with the failure that matches your timeline. Sudden worsening and gradual worsening usually have different roots.
If it changed fast, look for a disconnected or crushed duct. A flex run popping off its metal collar is the single most common 'it got bad overnight' cause techs find in attics.
If it crept up over a year or two, suspect leaks and sagging insulation. Mastic dries out, cloth tape peels, and jackets split. The system slowly bleeds air into places you're not trying to heat or cool.
Dampers and zone actuators sit in the middle. A handle bumped during other work, or a dead zone motor, can shift the balance without warning.
Return air problems are less common as the root of room-to-room unevenness, but a choked filter or blocked return makes everything else worse, so rule those out first because they're free to check.